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KMID : 0882420150890020169
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Korean Journal of Medicine
2015 Volume.89 No. 2 p.169 ~ p.178
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Recent Advances in the Management of Autosomal Dominant Polycystic Kidney Disease
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Park Hayne
Hwang Young-Hwan
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Abstract
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Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by the dysregulated growth of kidney cysts, resulting in end-stage kidney failure. By identifying the genes involved in ADPKD and detailing the molecular pathology of the disease, putative therapeutic agents have been developed. However, clinical trials of vasopressin receptor antagonists and somatostatin analogues have raised several concerns among researchers and clinicians. Questions regarding when and who to treat and what surrogate marker to use for describing endpoints have been raised. This review focuses on the current methods for managing ADPKD and describes recent findings from clinical trials. The main difficulties associated with implementing therapeutic agents in patients with ADPKD and considerations for clinical settings will also be discussed.
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KEYWORD
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Polycystic kidney diseases, Renal insufficiency, Chronic, Hypertension
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